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Anand Singh
PhD (Vanderbilt University)
Associate Professor, Department of Chemistry
FB436 ,
Department of Chemistry
IIT Kanpur,
Kanpur 208016
Specialization
Synthetic Organic Chemistry
Education
PhD (2009) Vanderbilt University, USA.
M. Sc. (2004) Indian Institute of Technology Bombay.
Selected Publications
A Diastereo- and Enantioselective Synthesis of α-Substituted syn-α,β-Diamino Acids,J. Am. Chem. Soc., 130, 5866 (2008). (Highlighted in Syn. facts 2008, 7, 0757).
Chiral Proton Catalysis: Enantioselective Brønsted Acid Catalyzed Additions of Nitroacetic Derivatives as Glycine Equivalents,J. Am. Chem. Soc., 129, 3466 (2007).
A [3+2] Cycloaddition Route to 3-Hydroxy-3-Alkyl Oxindoles: An Approach to Pyrrolidinoindoline Alkaloids,Org. Lett., 13, 2118 (2011).
Efficient Assembly of 3-Substituted Oxindole-based Isoxazolines Leadingto the Synthesis of (±)-Flustraminol-B and related Natural Product Building Blocks,Tetrahedron Lett., 53, 4889 (2012).
Synthesis of OxindolylPyrazolinesand 3-Amino Oxindole Building Blocks via a Nitrile Imine [3+2] Cycloaddition Strategy,Org. Lett., 14, 5266 (2012).
Awards & Fellowships
Mitchum E. Warren Fellowship
Research and University Graduate School Fellowship
Professional Experience
Postdoctoral Associate, Sanford-Burnham Medical Research Institute at Lake Nona, Orlando-FL, U.S.A., 2009-2012; IIT Kanpur, 2013-
Current Research
Our recently established research group at IITK has research interests broadly encompassing the areas of enantioselective catalysis, development of new reactions, and medicinal chemistry.
The unifying theme of our research is the development of new and efficient chemical transformations in order to create novel small molecule organics for potential applications in the fields of medicine, material science, and agrochemicals. One of our programs focuses on the development of novel fluorination reactions. Owing to the important applications of fluorinated compounds as drugs, diagnostic tools (PET imaging), and as agrochemicals, the synthesis of such molecules is of contemporary interest, and our lab is exploring the synthesis of novel fluorinated small molecules by developing fluorination strategies that employ fluoride anion as the source of fluorine. In addition to expanding the fluorinated chemical space, this strategy will lead to a more economical approach toward fluorinated compounds as opposed to the vast majority of current methods that employ electrophilic fluorination reagents.
A second area of research in our laboratory is photoredox catalysis wherein we aim to develop visible-light mediated reactions. Visible light represents an abundant, inexpensive, and clean source of energy and through its synergistic use with a suitable catalyst, it has been possible to activate certain types of organic molecules toward interesting, novel, and useful reactions. We are investigating a variety of olefin functionalization and cyclization reactions that will result in novel scaffolds that are valuable synthetic intermediates and also represent novel chemical spaces relevant to drug discovery and chemical biology