CHM202A - Basic Organic Chemistry -II
Prerequisites: CHM 301; CHM 203 (New ARC)CHM203A
3-0-0-9
Course Contents
Oxidation: With Cr and Mn compounds; with peracids and other peroxides; with periodic acid, Pb (OAc)4,Hg (OAc)2 and SeO2.Reduction: Catalytic hydrogenation; metal hydride, dissolving metal and hydrazine based reductions. Cram Felkin Anh model. CC Bond Formation : Acyloin, Aldol, Stobbe, Claisen, Knovenagel and Benzoin condensations, Darzens glycidic ester synthesis; Dieckmann reactions, Wittig reaction, Diels Alder and ene reactions, Reformatsky reaction. Aceto acetic ester and malonic ester synthesis. Acylation reactions. Enamine reactions. Gattermannaldehyde synthesis. Michael and Mannich reactions. Synthesis o f Poly nuclear Hydrocarbons: Carbohydrate Chemistry: Introduction, Structural elucidation and some typical eactions of mono and dischharides Heterocyclic Chemistry: Furan, Pyrrole, Thiophene, Pyridine, Indole, quino lines etc. Problems: (9)Based on multi step reactions involving CC bond formation, oxidation and Reduction (to be solved in the class and supplemented by home assignments).
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Books and References
Carruthers, W., Coldham, I. Some Modern Methods of Organic Synthesis, 2008.
.House, H. O., Modern Synthetic Reactions.
March, J., Advanced Organic Chemistry, 4th ed, 1999.
Clayden, Greeves, Warren, and Wothers, Organic Chemistry, 1st ed, 2001.
R. Bruckner, Advanced Organic Chemistry, 2002
R. Bruckner, Organic Mechanisms, 2010
M. B. Smith, Organic Synthesis, 3rd Ed. 2010