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Nagma Parveen
PhD (University of Muenster)
Assistant Professor, Department of Chemistry
Room No. 437 ,
Department of Chemistry
IIT Kanpur,
Kanpur 208016
Specialization
Soft Matter, Biomimetic Nanoparticles, Virus-like Particles, Viruses Polymer Swelling, Surface Functionalization, Single Particle Imaging Surface-sensitive Analytical Techniques (QCM-D, SPR), Fluorescence Microscopy
Education
PhD (2014) University of Muenster, Muenster, Germany
MSc (2010) Indian Institute of Technology, Chennai, India
BSc (2008) University of Calcutta (Lady Brabourne College), Kolkata, India
Teaching Area
Physical Chemistry
Biophysical Chemistry
Spectroscopy
Fluorescence Imaging
Selected Publications
Parveen N.*, Rydell G., Larsson G., Hytonen V., Zhdanov V., Hook F.* and Block S.*, “Competition for Membrane Receptors: Norovirus Detachment via Lectin Attachment” J. Am. Chem. Soc. 2019, 141(41), 16303-16311, doi.org/10.1021/jacs.9b06036
Parveen N., Rimkute I., Block S., Rydell G., Midtvedt D., Larsson G., Hytonen V., Zhdanov V., Lundgren A., and Hook F., “Membrane Deformation Induces Clustering of Norovirus Bound to Glycosphingolipids in a Supported Cell-Membrane Mimic”, J. Phys. Chem. Lett., 2018, 9(9), 2278-2284, DOI: 10.1021/acs.jpclett.8b00433
Parveen N., Block S., Zhdanov V., Rydell G. and Hook F., “Detachment of Membrane Bound Virions by Competitive Ligand-Binding Induced Receptor Depletion”, Langmuir ACS Editor’s Choice, 2017, 33 (16), 4049-4056 DOI: 10.1021/acs.langmuir.6b04582
Zetterberg M., Ahlgren S., Hernandez V., Parveen N. and Edwards K., “Optimization of Lipodisk Properties by Modification of the Extent and Density of the PEG Corona”, J. Colloid Interface Sci., 2016, 484, 86-96 DOI: jcis.2016.08.067
Parveen N.*, Jana K. P., and Schoenhoff M.*, “Viscoelastic Properties of Polyelectrolyte Multilayers Swollen with Ionic Liquid Solutions” Polymers, 2019, 11(8), 1285, https://doi.org/10.3390/polym11081285
Parveen N. and Schoenhoff M., “Swelling and Stability of Polyelectrolyte Multilayers in Ionic Liquid Solution”, Macromolecules, 2013, 6 (19), 7880-7888, DOI: 10.1021/ma401625r
Professional Experience
Assistant Professor, IIT Kanpur, February 2020
Postdoctoral Researcher, University of Leuven, Belgium, 2017-2019
Postdoctoral Researcher, Chalmers University of Technology, Sweden, 2014-2017
Current Research
Viruses are functional biological nanoparticles and also classified as a soft matter system. While viruses majorly related with diseases, they are known to have a crucial role in the genomic evolution as 5-8 % of human genome are comprised of endogenous retroviral genome. The first step of virus infection at cellular level is the attachment of virus nanoparticles to the plasma membrane via specific membrane receptors or attachment factors. This virus-receptor interaction is specific and that is why viruses can infect only specific cell types, typically, called as host cells.
The attachment-detachment kinetics of viruses to the plasma membrane is a complex process and multivalent in nature. Therefore, biomimetic functionalized surfaces are often used as model systems to better understand the fundamentals of virus binding. My research group will utilize different functionalized surfaces for specific binding of viruses and thereafter, scrutinize their binding kinetics and thermodynamics at both ensemble and single particle level. The long-term goal will be to use the functionalized platforms for capturing viruses with greater specificity and their detection at single virus level. The next step of the work will be method development for examining the virus attachment-detachment to their host cells. For this, a novel imaging approach known as expansion microscopy will be established in my group with an aim to achieve super-resolved images of viruses on/in the host cells. Application of the method will provide an enhanced spatial resolution (up to 20 nm) for imaging the interaction between virus and cellular factors in a greater detail.