Dattatraya H. Dethe

The total synthesis of natural products (usually biologically active) or organic compounds having theoretical interests in chemistry or biology is still as healthy and vigorous as ever. The journey of total synthesis was started in early nineteenth century. In the year 1828 Friedrich Wohler did the first total synthesis of urea, which can be considered as the birth of total synthesis. Now, in 21st century for the determination of structure and architecture of a molecule so many powerful techniques are established. These tools allow the chemists to think for the synthesis of some highly complex molecules which cannot be even imagined in the earlier era of organic synthesis.
        The research of our group is mainly focused on the development of new synthetic methods and strategies, and their application in the total synthesis of natural products and biologically important compounds. A major thrust of our current research is the design and invention of new annulation strategies for the synthesis of carbocyclic and heterocyclic systems. Our research program is focused on the development of new reagents and methods for organic synthesis, with an emphasis on asymmetric catalysis. The achievement of our objectives requires an understanding of stereoselective synthesis, physical organic chemistry, and metal-based reactivity.